期刊
NEUROLOGY
卷 95, 期 13, 页码 E1897-E1905出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.0000000000010013
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资金
- French National Foundation on Alzheimer's Disease and Related Disorders
- LABEX (Laboratory of Excellence Program Investment for the Future) DISTALZ grant
- Inserm
- Institut Pasteur de Lille
- Lille University Hospital
- Universite de Lille 2
- Medical Research Council [503480]
- Alzheimer's Research UK [503176]
- Wellcome Trust [082604/2/07/Z]
- German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) [01GI0102, 01GI0711, 01GI0420]
- NIH/NIA [R01 AG033193, U01 AG032984, U24 AG021886, U01 AG016976]
- NIA [AG081220]
- AGES contract [N01-AG-12100]
- NHLBI [R01 HL105756]
- Icelandic Heart Association
- Erasmus Medical Center
- Erasmus University
- Alzheimer's Association [ADGC-10-196728]
Objective Evidence from observational studies for the effect of physical activity on the risk of Alzheimer disease (AD) is inconclusive. We performed a 2-sample mendelian randomization analysis to examine whether physical activity is protective for AD. Methods Summary data of genome-wide association studies on physical activity and AD were used. The primary study population included 21,982 patients with AD and 41,944 cognitively normal controls. Eight single nucleotide polymorphisms (SNPs) known atp< 5 x 10(-8)to be associated with average accelerations and 8 SNPs associated atp< 5 x 10(-7)with vigorous physical activity (fraction of accelerations >425 milligravities) served as instrumental variables. Results There was no association between genetically predicted average accelerations with the risk of AD (inverse variance weighted odds ratio [OR] per SD increment: 1.03, 95% confidence interval 0.97-1.10,p= 0.332). Genetic liability for fraction of accelerations >425 milligravities was unrelated to AD risk. Conclusion The present study does not support a causal association between physical activity and risk of AD.
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