期刊
NEUROBIOLOGY OF AGING
卷 95, 期 -, 页码 195-204出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2020.07.025
关键词
Electrophysiology; Aging; Mouse; Dopamine; Substantia nigra; Firing
资金
- National Institute on Aging/NIH [R01 AG052606, P30 AG050911, F31 AG064861, T32 AG052363]
- Presbyterian Health Foundation
- Oklahoma Center for Adult Stem Cell Research (OCASCR)
Degeneration of substantia nigra pars compacta dopamine neurons is a central feature in the pathology of Parkinson's disease, which is characterized by progressive loss of motor and cognitive functions. The largest risk factors for Parkinson's disease are age and sex; most cases occur after age 60 and males have nearly twice the incidence as females. Preclinical work has scarcely considered the influence of these 2 factors to disease risk and presentation. Here, we observed a progressive decline in dopamine neuron firing activity in male C57BL/6 mice by 18 months of age, while dopamine neurons from females remained largely unaffected. This was accompanied by increased mRNA expression of PINK1 in both males and females, and PARK2 primarily in males, both of which have been linked to Parkinson's. Since the declining cell properties were accompanied by only slight decreases in locomotion in both sexes, it is likely that these age-related impairments in males represent a vulnerability to further insults that could predispose the neurons to neurodegenerative processes such as in Parkinson's. (C) 2020 Elsevier Inc. All rights reserved.
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