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NATURE GENETICS (2007)
Up-regulation of bcl-2 through ERK phosphorylation is associated with human macrophage survival in an estrogen microenvironment
Manikandan Subramanian et al.
JOURNAL OF IMMUNOLOGY (2007)
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
Tilo Kunath et al.
DEVELOPMENT (2007)
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Bhaswati Pandit et al.
NATURE GENETICS (2007)
ERK implication in cell cycle regulation
Jean-Claude Chambard et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL
Katherine E. Ewings et al.
EMBO JOURNAL (2007)
ERK activity and G1 phase progression: Identifying dispensable versus essential activities and primary versus secondary targets
Jessie Villanueva et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Balancing BMP signaling through integrated inputs into the Smad1 linker
Gopal Sapkota et al.
MOLECULAR CELL (2007)
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Ilias Mylonis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
S6K1- and βTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
N. Valerio Dorrello et al.
SCIENCE (2006)
Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation
Miho Kawamura-Saito et al.
HUMAN MOLECULAR GENETICS (2006)
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity
David Shahbazian et al.
EMBO JOURNAL (2006)
The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy
Aarati Ranganathan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Paxillin phosphorylation at ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics
Anjana Nayal et al.
JOURNAL OF CELL BIOLOGY (2006)
Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling
V Stefanovsky et al.
MOLECULAR CELL (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Subcellular localization determines MAP kinase signal output
A Harding et al.
CURRENT BIOLOGY (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
SS Grewal et al.
NATURE CELL BIOLOGY (2005)
c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
C Grandori et al.
NATURE CELL BIOLOGY (2005)
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
A Arabi et al.
NATURE CELL BIOLOGY (2005)
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
L Chen et al.
MOLECULAR CELL (2005)
Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
LJ Sundberg-Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways
XX Qi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry
T Lee et al.
MOLECULAR CELL (2004)
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
E Yeh et al.
NATURE CELL BIOLOGY (2004)
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin a on an important regulatory site
MS Woo et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
ST Eblen et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
DJ Webb et al.
NATURE CELL BIOLOGY (2004)
ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
L Le Gallic et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal
M Karlsson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mouse development and cell proliferation in the absence of D-cyclins
K Kozar et al.
CELL (2004)
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation
G Poortinga et al.
EMBO JOURNAL (2004)
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
T Ueda et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
AM Domina et al.
ONCOGENE (2004)
A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration
LO Murphy et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP
N Martinez-Quiles et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
S Ishibe et al.
MOLECULAR CELL (2004)
Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization
N Fujita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval
B Bozon et al.
NEURON (2003)
PAKI phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
JK Slack-Davis et al.
JOURNAL OF CELL BIOLOGY (2003)
Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf→ MEK→ ERK pathway
MA Woodrow et al.
EXPERIMENTAL CELL RESEARCH (2003)
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
LA Allan et al.
NATURE CELL BIOLOGY (2003)
The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB
ZA Felton-Edkins et al.
EMBO JOURNAL (2003)
ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis
AA Brahmbhatt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at Synapses
F Zalfa et al.
CELL (2003)
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
J Zhao et al.
MOLECULAR CELL (2003)
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis
S Ishibe et al.
MOLECULAR CELL (2003)
Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1
BM Iritani et al.
EMBO JOURNAL (2002)
Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1
MS Squires et al.
BIOCHEMICAL JOURNAL (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Molecular interpretation of ERK signal duration by immediate early gene products
LO Murphy et al.
NATURE CELL BIOLOGY (2002)
ERK2 enters the nucleus by a carrier-independent mechanism
AW Whitehurst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
MSK1 and MSK2 are required for the mitogen-and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
GR Wiggin et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway
LC Coles et al.
ONCOGENE (2002)
An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
VY Stefanovsky et al.
MOLECULAR CELL (2001)
The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1-and 2-mediated phosphorylation of serine 105 in cardiomyocytes
QR Liang et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase
E Formstecher et al.
DEVELOPMENTAL CELL (2001)
Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation
A Verger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
MW Jones et al.
NATURE NEUROSCIENCE (2001)
Growth-factor-dependent mitogenesis requires two distinct phases of signalling
SM Jones et al.
NATURE CELL BIOLOGY (2001)
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
R Sears et al.
GENES & DEVELOPMENT (2000)
Accelerated publication -: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
RC Osthus et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
VJ Fincham et al.
EMBO JOURNAL (2000)
Nuclear export of MAP kinase (ERK) involves a MAP kinase kinase (MEK)-dependent active transport mechanism
M Adachi et al.
JOURNAL OF CELL BIOLOGY (2000)
MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1
GZ Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Rsk1 mediates a MEK-MAP kinase cell survival signal
A Shimamura et al.
CURRENT BIOLOGY (2000)
Regulation of carbamoyl phosphate synthetase by MAP kinase
LM Graves et al.
NATURE (2000)
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