期刊
NATURE REVIEWS MICROBIOLOGY
卷 18, 期 11, 页码 637-648出版社
NATURE PORTFOLIO
DOI: 10.1038/s41579-020-0386-z
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资金
- Deutsche Forschungsgemeinschaft [WI3285/8-1]
- UK Biotechnology and Biological Sciences Research Council [BB/H018433/1, BB/F016603/1]
- Deutsche Zentrum fur Luft-und Raumfahrt [DLR01Kl1820]
- Swedish Research Council [2017-03783, 2015-04746, 2019-01085]
- Ragnar Soderbergs Stiftelse
- European Regional Development Fund through the Centre of Excellence for Molecular Cell Engineering, Molecular Infection Medicine Sweden
- Estonian Science Foundation [IUT2-22]
- Carl Tryggers Stiftelse forVetenskaplig Forskning [CTS 19:24]
- Kempestiftelserna [SMK1858.3]
- Jeanssons Stiftelser
- Umea Centre for Microbial Research gender policy programme
- Umea Universitet Insamlingsstiftelsen for Medicinsk Forskning
- Swedish Research Council within the RIBOTARGET consortium [2018-00956]
- Swedish Research Council [2019-01085, 2015-04746, 2018-00956] Funding Source: Swedish Research Council
- BBSRC [BB/H018433/1] Funding Source: UKRI
Antibiotic resistance is mediated through several distinct mechanisms, most of which are relatively well understood and the clinical importance of which has long been recognized. Until very recently, neither of these statements was readily applicable to the class of resistance mechanism known as target protection, a phenomenon whereby a resistance protein physically associates with an antibiotic target to rescue it from antibiotic-mediated inhibition. In this Review, we summarize recent progress in understanding the nature and importance of target protection. In particular, we describe the molecular basis of the known target protection systems, emphasizing that target protection does not involve a single, uniform mechanism but is instead brought about in several mechanistically distinct ways. During target protection, a resistance protein physically associates with an antibiotic target to rescue the latter from antibiotic-mediated inhibition. In this Review, O'Neill and colleagues describe the different molecular mechanisms underlying target protection and emphasize the importance of this phenomenon as a cause of clinically significant antibiotic resistance.
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