相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Circulating FGF21 Levels in Human Health and Metabolic Disease
Michaela Keuper et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2020)
Fibroblast growth factor (FGF)-21 based therapies: A magic bullet for nonalcoholic fatty liver disease (NAFLD)?
Michael Ritchie et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)
Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice
Hongshuai Li et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2020)
Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
Susanne Keipert et al.
NATURE COMMUNICATIONS (2020)
Whole-body and adipose tissue-specific mechanisms underlying the metabolic effects of fibroblast growth factor 21 in the Siberian hamster
Jo E. Lewis et al.
MOLECULAR METABOLISM (2020)
The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform
Karin Hultman et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2019)
Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues
Leiluo Geng et al.
CELL REPORTS (2019)
Exercise ameliorates the FGF21-adiponectin axis impairment in diet-induced obese mice
Wenqi Yang et al.
ENDOCRINE CONNECTIONS (2019)
NGM313, a Novel Activator of b-Klotho/FGFR1c, Improves Insulin Resistance and Reduces Hepatic Fat in Obese, Nondiabetic Subjects
Alex Depaoli et al.
DIABETES (2019)
Going Back to the Biology of FGF21: New Insights
Jo E. Lewis et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)
Improved FGF21 Sensitivity and Restored FGF21 Signaling Pathway in High-Fat Diet/Streptozotocin-Induced Diabetic Rats After Duodenal-Jejunal Bypass and Sleeve Gastrectomy
Qiaoran Liu et al.
FRONTIERS IN ENDOCRINOLOGY (2019)
Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases
Longwei Zhao et al.
EBIOMEDICINE (2019)
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
Yong Pan et al.
JOURNAL OF CLINICAL INVESTIGATION (2019)
Pegbelfermin (BMS-986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study
Edgar D. Charles et al.
OBESITY (2019)
Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice
Brandon L. Panaro et al.
MOLECULAR METABOLISM (2019)
A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway
Lichen Bao et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
Cheng-Chao Ruan et al.
CELL METABOLISM (2018)
FGF Family: From Drug Development to Clinical Application
Qi Hui et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
Birgitte Andersen et al.
INTERNATIONAL JOURNAL OF OBESITY (2018)
A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity
Sally Yu Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
BMS-986036, a PEGylated fibroblast growth factor 21 analogue, reduces fibrosis and Pro-C3 in a mouse model of non-alcoholic steatohepatitis
Y. Luo et al.
JOURNAL OF HEPATOLOGY (2018)
Effects of a PEGylated fibroblast growth factor 21 variant on steatosis, inflammation, and fibrosis in a mouse model of non-alcoholic steatohepatitis
B. Zinker et al.
JOURNAL OF HEPATOLOGY (2018)
Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats
Umit Yilmaz et al.
JOURNAL OF PHYSIOLOGICAL SCIENCES (2018)
Hepatic regulation of VLDL receptor by PPAR beta/delta and FGF21 modulates non-alcoholic fatty liver disease
Mohammad Zarei et al.
MOLECULAR METABOLISM (2018)
Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
Xiaoshan Min et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling
Sangwon Lee et al.
NATURE (2018)
Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial
Arun Sanyal et al.
LANCET (2018)
Fibroblast growth factor-21 restores insulin sensitivity but induces aberrant bone microstructure in obese insulin-resistant rats
Narattaphol Charoenphandhu et al.
JOURNAL OF BONE AND MINERAL METABOLISM (2017)
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
Shanaka Stanislaus et al.
ENDOCRINOLOGY (2017)
FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans
Ricardo J. Samms et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
Mark Z. Chen et al.
MOLECULAR METABOLISM (2017)
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates
Albert M. Kim et al.
DIABETES OBESITY & METABOLISM (2017)
FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
Tian Lan et al.
CELL METABOLISM (2017)
The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity
Zhe Huang et al.
CELL METABOLISM (2017)
FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice
Fan Wu et al.
CLINICAL SCIENCE (2017)
Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
Longwei Zhao et al.
BMC BIOTECHNOLOGY (2017)
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms
Lucas BonDurant et al.
CELL METABOLISM (2017)
Circulating FGF21 proteolytic processing mediated by fibroblast activation protein
Eugene Y. Zhen et al.
BIOCHEMICAL JOURNAL (2016)
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
Chiara Degirolamo et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
Expression Atlas update-an integrated database of gene and protein expression in humans, animals and plants
Robert Petryszak et al.
NUCLEIC ACIDS RESEARCH (2016)
FAP finds FGF21 easy to digest
Matthew P. Gillum et al.
BIOCHEMICAL JOURNAL (2016)
FGF21 Regulates Sweet and Alcohol Preference
Saswata Talukdar et al.
CELL METABOLISM (2016)
A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
Saswata Talukdar et al.
CELL METABOLISM (2016)
FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
Christian Schlein et al.
CELL METABOLISM (2016)
FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
Stephanie von Holstein-Rathlou et al.
CELL METABOLISM (2016)
FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency
Lucile Dollet et al.
DIABETES (2016)
Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity
Ricardo J. Samms et al.
ENDOCRINOLOGY (2016)
Fibroblast Growth Factor 21 Improves Hepatic Insulin Sensitivity by Inhibiting Mammalian Target of Rapamycin Complex 1 in Mice
Qi Gong et al.
HEPATOLOGY (2016)
Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21
Diana Ronai Dunshee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
W. Clayton Thompson et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2016)
Fibroblast growth factor 21 attenuates hepatic fibrogenesis through TGF-β/smad2/3 and NF-κB signaling pathways
Pengfei Xu et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2016)
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
Annabel Y. Minard et al.
CELL REPORTS (2016)
Fibroblast activation protein (FAP) as a novel metabolic target
Miguel Angel Sanchez-Garrido et al.
MOLECULAR METABOLISM (2016)
Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
Leigang Jin et al.
DIABETES & METABOLISM JOURNAL (2016)
Human FGF-21 Is a Substrate of Fibroblast Activation Protein
Andrew L. Coppage et al.
PLOS ONE (2016)
FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
Yusuke Joki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
Xunde Wang et al.
CELL METABOLISM (2015)
Pharmacologic Effects of FGF21 Are Independent of the Browning'' of White Adipose Tissue
Murielle M. Veniant et al.
CELL METABOLISM (2015)
Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice
Zhuofeng Lin et al.
CIRCULATION (2015)
Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway
Chi Zhang et al.
DIABETOLOGIA (2015)
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice
Nicholas Douris et al.
ENDOCRINOLOGY (2015)
FGF21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation
Xiaoqing Yan et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)
FGF21 and the late adaptive response to starvation in humans
Pouneh K. Fazeli et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
Michelle M. Kwon et al.
CELL REPORTS (2015)
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
Ricardo J. Samms et al.
CELL REPORTS (2015)
FGF21 and cardiac physiopathology
Anna Planavila et al.
FRONTIERS IN ENDOCRINOLOGY (2015)
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
Ganesh Kolumam et al.
EBIOMEDICINE (2015)
Fibroblast growth factor 21 protects the heart from oxidative stress
Anna Planavila et al.
CARDIOVASCULAR RESEARCH (2015)
Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress
Seong Hun Kim et al.
DIABETOLOGIA (2015)
Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
J. M. Gallego-Escuredo et al.
INTERNATIONAL JOURNAL OF OBESITY (2015)
Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue
Mohamed Asrih et al.
PLOS ONE (2015)
FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
Bryn M. Owen et al.
CELL METABOLISM (2014)
FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting
Qingning Liang et al.
DIABETES (2014)
Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
Kathleen R. Markan et al.
DIABETES (2014)
Fibroblast Growth Factor 21 Limits Lipotoxicity by Promoting Hepatic Fatty Acid Activation in Mice on Methionine and Choline-Deficient Diets
Ffolliott M. Fisher et al.
GASTROENTEROLOGY (2014)
Fibroblast Growth Factor 21 Protects Against Acetaminophen-Induced Hepatotoxicity by Potentiating Peroxisome Proliferator-Activated Receptor Coactivator Protein-1α-Mediated Antioxidant Capacity in Mice
Dewei Ye et al.
HEPATOLOGY (2014)
Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis
Manoja K. Brahma et al.
JOURNAL OF LIPID RESEARCH (2014)
MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
Ting Fu et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
Daniel A. Bachovchin et al.
NATURE CHEMICAL BIOLOGY (2014)
Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy
Elizabeth J. Hamson et al.
PROTEOMICS CLINICAL APPLICATIONS (2014)
Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
Zhuofeng Lin et al.
CELL METABOLISM (2013)
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
William L. Holland et al.
CELL METABOLISM (2013)
The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
Gregory Gaich et al.
CELL METABOLISM (2013)
High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets Involvement of Peroxisome Proliferator-Activated Receptor γ Signaling
Wing Yan So et al.
DIABETES (2013)
Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
Raul C. Camacho et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China
Huating Li et al.
JOURNAL OF HEPATOLOGY (2013)
Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans
J. Lundberg et al.
JOURNAL OF INTERNAL MEDICINE (2013)
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
Angie L. Bookout et al.
NATURE MEDICINE (2013)
Rational Design of a Fibroblast Growth Factor 21-Based Clinical Candidate, LY2405319
Alexei Kharitonenkov et al.
PLOS ONE (2013)
Fibroblast growth factor 21 protects against cardiac hypertrophy in mice
A. Planavila et al.
NATURE COMMUNICATIONS (2013)
The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
Andrew C. Adams et al.
MOLECULAR METABOLISM (2013)
Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody
Jie Huang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
Paul A. Dutchak et al.
CELL (2012)
Selective Insulin and Leptin Resistance in Metabolic Disorders
A. Christine Koenner et al.
CELL METABOLISM (2012)
βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism
Xunshan Ding et al.
CELL METABOLISM (2012)
TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway
Julieta Diaz-Delfin et al.
ENDOCRINOLOGY (2012)
Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
Clarence Hale et al.
ENDOCRINOLOGY (2012)
FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis
Kenneth R. Feingold et al.
ENDOCRINOLOGY (2012)
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Ffolliott M. Fisher et al.
GENES & DEVELOPMENT (2012)
FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
Murielle M. Veniant et al.
PLOS ONE (2012)
Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
Randy Hecht et al.
PLOS ONE (2012)
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
Wei Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
Ian N. Foltz et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
Ffolliott M. Fisher et al.
ENDOCRINOLOGY (2011)
Growth Hormone Induces Hepatic Production of Fibroblast Growth Factor 21 through a Mechanism Dependent on Lipolysis in Adipocytes
Wei Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes
Xuan Ge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans
Paul Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)
Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
David A. Sarruf et al.
DIABETES (2010)
Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
Ffolliott M. Fisher et al.
DIABETES (2010)
Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
Klementina Fon Tacer et al.
MOLECULAR ENDOCRINOLOGY (2010)
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models-association with liver and adipose tissue effects
Jing Xu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice
Jing Xu et al.
DIABETES (2009)
Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity
Eric D. Berglund et al.
ENDOCRINOLOGY (2009)
Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis
Michael K. Badman et al.
ENDOCRINOLOGY (2009)
Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver
Yuhei Hotta et al.
ENDOCRINOLOGY (2009)
FGF21 N- and C-termini play different roles in receptor interaction and activation
Junming Yie et al.
FEBS LETTERS (2009)
Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
Xiaofan Li et al.
FEBS LETTERS (2009)
Different Roles of N- and C-Termini in the Functional Activity of FGF21
Radmila Micanovic et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Circulating Fibroblast Growth Factor 21 Is Induced by Peroxisome Proliferator-Activated Receptor Agonists But Not Ketosis in Man
Constantinos Christodoulides et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Cold-Activated Brown Adipose Tissue in Healthy Men
Wouter D. van Marken Lichtenbelt et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
Matthew J. Potthoff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man
Cecilia Gaelman et al.
CELL METABOLISM (2008)
Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
Xinmei Zhang et al.
DIABETES (2008)
Fibroblast Growth Factor 21 Corrects Obesity in Mice
Tamer Coskun et al.
ENDOCRINOLOGY (2008)
FGF21 attenuates lipolysis in human adipocytes -: A possible link to improved insulin sensitivity
Peter Arner et al.
FEBS LETTERS (2008)
Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor Isoforms determines metabolic activity of FGF19 and FGF21
Hiroshi Kurosu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states
Michael K. Badman et al.
CELL METABOLISM (2007)
Endocrine regulation of the fasting response by PPARα-mediated induction of fibroblast growth factor 21
Takeshi Inagaki et al.
CELL METABOLISM (2007)
βKlotho is required for metabolic activity of fibroblast growth factor 21
Yasushi Ogawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
Alexei Kharitonenkov et al.
ENDOCRINOLOGY (2007)
Molecular determinants of FGF-21 activity-synergy and cross-talk with PPAR gamma signaling
Julie S. Moyers et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2007)
Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis
Xinqiang Huang et al.
MOLECULAR CARCINOGENESIS (2006)
FGF-21 as a novel metabolic regulator
A Kharitonenkov et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
XT Liu et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
T Yamauchi et al.
NATURE MEDICINE (2001)
分享论文
