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Are Major Dementias Triggered by Poor Blood Flow to the Brain? Theoretical Considerations
Jack C. de la Torre
JOURNAL OF ALZHEIMERS DISEASE (2017)
A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer's Disease: Preliminary Results from a Neuroimaging Study
Christian-Alexandre Castellano et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer's Disease Subjects: Results of a Single-Arm, Pilot Trial
Heather M. Wilkins et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements
Shona A. Mookerjee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease
Robert J. Pawlosky et al.
JOURNAL OF NEUROCHEMISTRY (2017)
Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model
Seung Hyun Baek et al.
JOURNAL OF NEUROSCIENCE (2017)
The Vicious Circle of Hypometabolism in Neurodegenerative Diseases: Ways and Mechanisms of Metabolic Correction
Yuri Zilberter et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2017)
Triheptanoin for the Treatment of Brain Energy Deficit: A 14-Year Experience
Fanny Mochel
JOURNAL OF NEUROSCIENCE RESEARCH (2017)
Treating cognitive impairment with transcranial low level laser therapy
Jack C. de la Torre
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2017)
How the cognitive reserve interacts with β-amyloid deposition in mitigating FDG metabolism An observational study
Elena Carapelle et al.
MEDICINE (2017)
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Vincenzo Sorrentino et al.
NATURE (2017)
Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galactose-induced aging mice
Farzad Salehpour et al.
NEUROBIOLOGY OF AGING (2017)
Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes
Na Zhao et al.
NEURON (2017)
GLUT4 Mobilization Supports Energetic Demands of Active Synapses
Ghazaleh Ashrafi et al.
NEURON (2017)
A randomized trial of relamorelin for constipation in Parkinson's disease (MOVE-PD): Trial results and lessons learned
Ronald F. Pfeiffer et al.
PARKINSONISM & RELATED DISORDERS (2017)
FDG-PET in Creutzfeldt-Jakob disease: Analysis of clinical-PET correlation
Dimitri Renard et al.
PRION (2017)
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
Mark J. Millan
PROGRESS IN NEUROBIOLOGY (2017)
Ketogenic diet in the treatment of schizoaffective disorder: Two case studies
Christopher M. Palmer
SCHIZOPHRENIA RESEARCH (2017)
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
Audrey S. Dickey et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Amylin and Leptin: Co-Regulators of Energy Homeostasis and Neuronal Development
Barry E. Levin et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
Amylin Receptor: A Potential Therapeutic Target for Alzheimer's Disease
Wen Fu et al.
TRENDS IN MOLECULAR MEDICINE (2017)
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology
Tal Nuriel et al.
NATURE COMMUNICATIONS (2017)
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
Cecilie Morland et al.
NATURE COMMUNICATIONS (2017)
Monitoring ATP dynamics in electrically active white matter tracts
Andrea Trevisiol et al.
ELIFE (2017)
Emerging Roles for Glycogen in the CNS
Alice E. Waitt et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease
Philip S. Insel et al.
FRONTIERS IN NEUROSCIENCE (2017)
Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments
Tesfaye W. Tefera et al.
FRONTIERS IN NEUROSCIENCE (2017)
Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease
Simone Bido et al.
SCIENTIFIC REPORTS (2017)
Suppression of adiponectin receptor 1 promotes memory dysfunction and Alzheimer's disease-like pathologies
Min Woo Kim et al.
SCIENTIFIC REPORTS (2017)
The effects of sitagliptin, a DPP-4 inhibitor, on cognitive functions in elderly diabetic patients with or without Alzheimer's disease
Ahmet Turan Isik et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2017)
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study
Ryan W. Dellinger et al.
NPJ AGING AND MECHANISMS OF DISEASE (2017)
DPP4 Inhibitors Can Be a Drug of Choice for Type 3 Diabetes: A Mini Review
Nehru Sai Suresh Chalichem et al.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2017)
Retinal metabolism: A comparative look at energetics in the retina
Michael W. Country
BRAIN RESEARCH (2017)
The mechanisms of action of metformin
Graham Rena et al.
DIABETOLOGIA (2017)
Loss of Brain Aerobic Glycolysis in Normal Human Aging
Manu S. Goyal et al.
CELL METABOLISM (2017)
Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?
Veronica Morea et al.
AMINO ACIDS (2017)
Central Regulation of Glucose Homeostasis
Alexander Tups et al.
COMPREHENSIVE PHYSIOLOGY (2017)
Gut-Brain Glucose Signaling in Energy Homeostasis
Maud Soty et al.
CELL METABOLISM (2017)
Brain metabolism in health, aging, and neurodegeneration
Simonetta Camandola et al.
EMBO JOURNAL (2017)
Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study
Aaron M. Koenig et al.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2017)
Energy defects in Huntington's disease: Why in vivo evidence matters
Geraldine Liot et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks
Sonia C. Correia et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)
N-acetylcysteine protects memory decline induced by streptozotocin in mice
Michael Costa et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Peripheral Blood Adipokines and Insulin Levels in Patients with Alzheimer's Disease: A Replication Study and Meta-Analysis
Jing Ma et al.
CURRENT ALZHEIMER RESEARCH (2016)
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes
Ele Ferrannini et al.
DIABETES (2016)
The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
Dilan Athauda et al.
DRUG DISCOVERY TODAY (2016)
Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ
David M. Stucki et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial
Jose A. Luchsinger et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis
Fahmeed Hyder et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)
Oxaloacetate enhances neuronal cell bioenergetic fluxes and infrastructure
Heather M. Wilkins et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Novel incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells
Jaishree Jalewa et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease
Jacqueline A. Bayliss et al.
JOURNAL OF NEUROSCIENCE (2016)
The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders
Mark J. Millan et al.
JOURNAL OF PSYCHOPHARMACOLOGY (2016)
Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism
Rebekah M. Ahmed et al.
LANCET NEUROLOGY (2016)
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Zhongyu Xie et al.
MOLECULAR CELL (2016)
The interneuron energy hypothesis: Implications for brain disease
Oliver Kann
NEUROBIOLOGY OF DISEASE (2016)
Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism
Aiman S. Saab et al.
NEURON (2016)
Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis
Tesfaye W. Tefera et al.
PLOS ONE (2016)
Intermediates of Metabolism: From Bystanders to Signalling Molecules
Robert Haas et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport
Maria-Victoria Hinckelmann et al.
NATURE COMMUNICATIONS (2016)
In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial
Michael Gejl et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia
B. Dean et al.
TRANSLATIONAL PSYCHIATRY (2016)
Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer's Disease
Stephen C. Cunnane et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)
Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan
Mario Baumgart et al.
CELL SYSTEMS (2016)
Shining light on the head: Photobiomodulation for brain disorders
Michael R. Hamblin
BBA CLINICAL (2016)
Exogenous β-amyloid peptide interferes with GLUT4 localization in neurons
Leandro T. Oliveira et al.
BRAIN RESEARCH (2015)
Adult Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise?
Ang Li et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2015)
Rapid adaptation of rat brain and liver metabolism to a ketogenic diet: an integrated study using 1H- and 13C-NMR spectroscopy
Maggie Roy et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)
Non-signalling energy use in the brain
Elisabeth Engl et al.
JOURNAL OF PHYSIOLOGY-LONDON (2015)
Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis
S. T. Ngo et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2015)
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Tiia Ngandu et al.
LANCET (2015)
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Mark F. McCarty et al.
MEDICAL HYPOTHESES (2015)
Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience
Charles R. Roe et al.
MOLECULAR GENETICS AND METABOLISM (2015)
Perimenopause as a neurological transition state
Roberta D. Brinton et al.
NATURE REVIEWS ENDOCRINOLOGY (2015)
The role of type 2 diabetes in neurodegeneration
Giuseppe Verdile et al.
NEUROBIOLOGY OF DISEASE (2015)
Triheptanoin improves brain energy metabolism in patients with Huntington disease
Isaac Mawusi Adanyeguh et al.
NEUROLOGY (2015)
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T. M. Schwarzkopf et al.
NEUROSCIENCE (2015)
Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia
Ann Katrin Kraeuter et al.
SCHIZOPHRENIA RESEARCH (2015)
Exercise Pills: At the Starting Line
Shunchang Li et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance
Arnold Bakker et al.
NEUROIMAGE-CLINICAL (2015)
White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease
Lauren P. Klosinski et al.
EBIOMEDICINE (2015)
Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease
Liang Zhang et al.
EBIOMEDICINE (2015)
Cortical hypermetabolism in MCI subjects: a compensatory mechanism?
A. Ashraf et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)
Disturbed mitochondrial dynamics and neurodegenerative disorders
Florence Burte et al.
NATURE REVIEWS NEUROLOGY (2015)
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
Nicola Raule et al.
AGING CELL (2014)
Glucose hypometabolism is highly localized, but lower cortical thickness and brain atrophy are widespread in cognitively normal older adults
Scott Nugent et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)
Myelination of the Nervous System: Mechanisms and Functions
Klaus-Armin Nave et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
Scott A. Yuzwa et al.
CHEMICAL SOCIETY REVIEWS (2014)
Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis
Ernesto Miquel et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis
Maria A. Lim et al.
HUMAN MOLECULAR GENETICS (2014)
The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo
Golam M. I. Chowdhury et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)
Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution
Stephen C. Cunnane et al.
JOURNAL OF HUMAN EVOLUTION (2014)
Upregulation of GPR109A in Parkinson's Disease
Chandramohan Wakade et al.
PLOS ONE (2014)
Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex
Giulio Srubek Tomassy et al.
SCIENCE (2014)
Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin
Eileen M. Moore et al.
DIABETES CARE (2013)
Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain
Isaac Marin-Valencia et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)
Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease
Misha Zilberter et al.
JOURNAL OF NEUROCHEMISTRY (2013)
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
Yoshihiro Kashiwaya et al.
NEUROBIOLOGY OF AGING (2013)
Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models
Bing Gong et al.
NEUROBIOLOGY OF AGING (2013)
Dietary ketosis enhances memory in mild cognitive impairment
Robert Krikorian et al.
NEUROBIOLOGY OF AGING (2012)
The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
Meagan J. McManus et al.
JOURNAL OF NEUROSCIENCE (2011)
Ketogenic Diet Prevents Alterations in Brain Metabolism in Young but not Adult Rats after Traumatic Brain Injury
Ying Deng-Bryant et al.
JOURNAL OF NEUROTRAUMA (2011)
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
George Bartzokis
NEUROBIOLOGY OF AGING (2011)
A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease
David N. Ruskin et al.
PHYSIOLOGY & BEHAVIOR (2011)
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia
Kathleen A. Page et al.
DIABETES (2009)
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
Toshiyuki Nakamura et al.
MOLECULAR NEURODEGENERATION (2009)
Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial
Samuel T. Henderson et al.
NUTRITION & METABOLISM (2009)
Energy inhibition elevates β-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice:: Possible early events in Alzheimer's disease pathogenesis
RA Velliquette et al.
JOURNAL OF NEUROSCIENCE (2005)
Effects of β-hydroxybutyrate on cognition in memory-impaired adults
MA Reger et al.
NEUROBIOLOGY OF AGING (2004)
D-β-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease
K Tieu et al.
JOURNAL OF CLINICAL INVESTIGATION (2003)
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