期刊
NATURE NEUROSCIENCE
卷 23, 期 8, 页码 981-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-020-0651-5
关键词
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资金
- NIH [F31 105678, F32 DK112589-01, R01 DK109930, T32 5T32DK007516]
- NSF [GRFP 2016207224]
- Davis Family Foundation Postdoctoral Fellowship
- NIH Director's New Innovator Award [DP2 DK105570]
- McKnight Scholar Award
- Pew Scholar Award
- Smith Family Foundation Award
- Harvard Mind Brain Behavior Interfaculty Initiative Faculty Research Award
- Klarman Family Foundation
- American Federation for Aging Research
- Harvard Brain Science Initiative Bipolar Disorder Seed Grant
- RCN [250259]
Cellular imaging reveals that visual cue-evoked activity patterns in visual association cortex are reactivated during subsequent quiet waking. Reactivation rates scale with cue salience and predict next-day changes in functional connectivity and behavior. Salient experiences are often relived in the mind. Human neuroimaging studies suggest that such experiences drive activity patterns in visual association cortex that are subsequently reactivated during quiet waking. Nevertheless, the circuit-level consequences of such reactivations remain unclear. Here, we imaged hundreds of neurons in visual association cortex across days as mice learned a visual discrimination task. Distinct patterns of neurons were activated by different visual cues. These same patterns were subsequently reactivated during quiet waking in darkness, with higher reactivation rates during early learning and for food-predicting versus neutral cues. Reactivations involving ensembles of neurons encoding both the food cue and the reward predicted strengthening of next-day functional connectivity of participating neurons, while the converse was observed for reactivations involving ensembles encoding only the food cue. We propose that task-relevant neurons strengthen while task-irrelevant neurons weaken their dialog with the network via participation in distinct flavors of reactivation.
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