期刊
NATURE METHODS
卷 18, 期 8, 页码 873-880出版社
NATURE PORTFOLIO
DOI: 10.1038/s41592-020-0867-z
关键词
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资金
- National Natural Science Foundation [81972875]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT310028]
- CAMS Initiative for Innovative Medicine [2016-I2M-1-005]
T cells respond to threats by recognizing short peptide antigens presented on MHC proteins using T cell receptors, which determines their function in disease. Recent method developments have made progress in T cell antigen discovery, but there are still challenges to overcome.
T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that recognize short peptide antigens presented on major histocompatibility complex (MHC) proteins. The TCR-peptide-MHC interaction mediated between a T cell and its target cell dictates its function and thereby influences its role in disease. A lack of approaches for antigen discovery has limited the fundamental understanding of the antigenic landscape of the overall T cell response. Recent advances in high-throughput sequencing, mass cytometry, microfluidics and computational biology have led to a surge in approaches to address the challenge of T cell antigen discovery. Here, we summarize the scope of this challenge, discuss in depth the recent exciting work and highlight the outstanding questions and remaining technical hurdles in this field. A review on recent method development for discovering T cell antigens.
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