期刊
NATURE IMMUNOLOGY
卷 21, 期 8, 页码 831-832出版社
NATURE PORTFOLIO
DOI: 10.1038/s41590-020-0740-3
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- MRC [G0701703, G0902209, G0700149] Funding Source: UKRI
Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.
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