期刊
NATURE
卷 583, 期 7818, 页码 699-+出版社
NATURE RESEARCH
DOI: 10.1038/s41586-020-2493-4
关键词
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资金
- NCI NIH HHS [P30 CA045508, P30 CA014195, P30 CA008748] Funding Source: Medline
- NHGRI NIH HHS [U54 HG007004, U54 HG006996, R01 HG003143, U01 HG007037, U54 HG006998, U54 HG007005, U54 HG006997, UM1 HG009442, U24 HG009397, U01 HG009380, U01 HG009431, U24 HG009446, UM1 HG009390, T32 HG000044, U54 HG007002, U01 HG007033, U01 HG007036, F32 HG006993, U54 HG006991, U01 HG007019, U54 HG007010, K99 HG009530, UM1 HG009411, U54 HG006994, U41 HG007000, U41 HG006992] Funding Source: Medline
- NIDDK NIH HHS [R37 DK050107, R24 DK106766, R01 DK068634] Funding Source: Medline
- NIGMS NIH HHS [T32 GM087237, R01 GM083337] Funding Source: Medline
- BBSRC [BB/I025360/1] Funding Source: UKRI
The authors summarize the data produced by phase III of the Encyclopedia of DNA Elements (ENCODE) project, a resource for better understanding of the human and mouse genomes. The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (), including phase II ENCODE(1)and Roadmap Epigenomics(2)data. We have developed a registry of 926,535 human and 339,815 mouse candidatecis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN;) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes.
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