期刊
NATURE
卷 586, 期 7830, 页码 583-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41586-020-2607-z
关键词
-
资金
- Department of Health and Human Services Biomedical Advanced Research and Development Authority (BARDA) [HHS0100201700018C]
- Janssen Vaccines Prevention BV
- Ragon Institute of MGH, MIT, and Harvard
- Mark and Lisa Schwartz Foundation
- National Institutes of Health [OD024917, AI129797, AI124377, AI128751, AI126603, AI007151, AI152296, AI146779, 272201700036I-0-759301900131-1, AI100625, AI110700, AI132178, AI149644, AI108197]
- Burroughs Wellcome Fund Postdoctoral Enrichment Program Award
- Massachusetts Consortium on Pathogen Readiness (MassCPR)
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic(1-8). For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes(9,10). The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. The protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccine expressing the SARS-CoV-2 spike protein in non-human primates is demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据