Resorcinol derivatives with α-glucosidase inhibitory activities from Syzygium samarangense

Nine resorcinol derivatives including two new ones, 5-[(8Z,11Z,14Z)-nonadeca-8,11,14-trienyl] resorcinol (1) and 5-[(8Z,11Z,14E)-heptadeca-8,11,14-trienyl] resorcinol (2), were isolated from the leaves ofSyzygium samarangense. The new structures were elucidated by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Among them, compounds3,4,6 and 7 exhibited significant alpha-glucosidase inhibitory activities with IC50 of 3.16, 3.16, 2.34 and 0.99 mu M, respectively. This finding provides evidence that resorcinol derivatives with long aliphatic chain function as new promising antidiabetic alternatives. [GRAPHICS] .

Automated summary

Nine resorcinol derivatives, including two novel compounds, were isolated from the leaves of Syzygium samarangense. Among them, four compounds exhibited significant alpha-glucosidase inhibitory activities, indicating that resorcinol derivatives with long aliphatic chains may serve as promising antidiabetic alternatives.