期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 24, 页码 5948-5953出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1805606
关键词
Syzygium samarangense; resorcinol derivatives; alpha-glucosidase; inhibitory activity
资金
- National Natural Science Foundation of China [31560098, 81522044]
- National Key R&D Program of China [2018YFA0900600]
- Midaged and Young Academic and Technical Leader Raising Foundation of Yunnan Province, China [2010CI040]
Nine resorcinol derivatives, including two novel compounds, were isolated from the leaves of Syzygium samarangense. Among them, four compounds exhibited significant alpha-glucosidase inhibitory activities, indicating that resorcinol derivatives with long aliphatic chains may serve as promising antidiabetic alternatives.
Nine resorcinol derivatives including two new ones, 5-[(8Z,11Z,14Z)-nonadeca-8,11,14-trienyl] resorcinol (1) and 5-[(8Z,11Z,14E)-heptadeca-8,11,14-trienyl] resorcinol (2), were isolated from the leaves ofSyzygium samarangense. The new structures were elucidated by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Among them, compounds3,4,6 and 7 exhibited significant alpha-glucosidase inhibitory activities with IC50 of 3.16, 3.16, 2.34 and 0.99 mu M, respectively. This finding provides evidence that resorcinol derivatives with long aliphatic chain function as new promising antidiabetic alternatives. [GRAPHICS] .
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