期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 1, 页码 445-449出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1774764
关键词
Santolina; essential oil; anti-inflammatory; pro-inflammatory mediators; antifungal; germ tube; safety profile
资金
- Fundacao para a Ciencia e a Tecnologia (FCT) [UID/EQU/00102/2019]
- Fundação para a Ciência e a Tecnologia [UID/EQU/00102/2019] Funding Source: FCT
The study reveals that the essential oil of Santolina insularis can effectively reduce nitric oxide production, inhibit the expression of pro-inflammatory enzymes, and demonstrate significant antifungal activity, especially against Cryptococcus neoformans and most dermatophytes.
Santolina insularisis a Sardinian endemism that is widely used in traditional medicine. The essential oil was obtained with a yield of 2.7% and is mainly characterized by beta-phellandrene (22.6%), myrcene (11.4%) and artemisia ketone (7.6%). The oil significantly reduced NO production without affecting macrophages viability. In addition, it substantially inhibited the expression of two key pro-inflammatory enzymes, iNOS and COX-2 (71% and 25% at 0.54 mg/mL). Furthermore, the oil had a promising antifungal activity beingCryptococcus neoformans(MIC = 0.13 mg/mL) and the majority of dermatophytes (MIC = 0.13 mg/mL) the most susceptible fungi. Moreover, it significantly decreased the yeast-to-hypha transition (80% inhibition at 0.13 mg/mL) onC. albicanslong before showing inhibitory effects. Overall, these results show thatS. insulariscould be applied in the treatment of fungal infections and associated inflammatory response.
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