期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 1, 页码 488-492出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1786824
关键词
Medicinal plants; Inga edulis; dereplication; HPLC-SPE-TT; RP-HPLC-PDA; NMR
资金
- CNPq
- CAPES
- FAPESP
The study identified sixteen compounds from Inga edulis leaves extract using dereplication strategy, including triterpenes, flavonoids, phenolic acids, and anthocyanins. The species showed strong antioxidant potential with phenolic compounds as major constituents. The techniques used in this study provided effective strategies for the early detection of active natural products from plant extracts.
Inga edulisis traditionally used as anti-inflammatory and antidiarrheal and has been investigated as potential sources of biologically active natural products. In this study, dereplication strategy using HPLC-SPE-TT, RP-HPLC-PDA and NMR spectroscopy was employed, and this resulted in the identification of sixteen compounds from the leaves extract ofI. edulis, including four triterpenes (lupeol, alpha-amirin, olean-18-ene acid and frideline), three flavonoids, eight phenolic acids, an anthocyanin derived from delphinidin-3-glycoside and a mixture of five acylated anthocyanins. The chemical identification was performed based on NMR data, chemosystematics aspects, UV spectra and by comparison with the retention time and UV spectra of authentic standards. The metabolic profile of the species indicated the presence of phenolic compounds as major constituents justifying its strong antioxidant potential performed in beta-carotene test. The techniques used have shown effective strategies for the early detection of active natural products from plant extracts, as these approaches are still crucially absent. [GRAPHICS] .
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