Paratrimerin I, cytotoxic acridone alkaloid from the roots ofParamignya trimera

Bioactivity-guided fractionation of the CHCl3-soluble extract of the roots ofParamignya trimerawas carried out to obtain a new acridone alkaloid, paratrimerin I. Its structure was elucidated based on NMR spectroscopic data interpretation. Paratrimerin I showed noteworthy cytotoxicity against the HepG2 human hepatocellular and MCF-7 human breast carcinoma cell lines, with the submicromolar IC(50)values of 0.43 and 0.26 mu M, respectively. TheN-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton can be proposed as a structural feature for good cytotoxicity.

Automated summary

A new acridone alkaloid named paratrimerin I was isolated from the roots of Paramignya trimerawas through bioactivity-guided fractionation, and showed significant cytotoxicity against HepG2 and MCF-7 cell lines. The N-methyl, C-4 methoxy, and C-5 hydroxy groups in the acridone skeleton were suggested to contribute to its cytotoxic activity.