期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 29, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2020.102277
关键词
Nano-carrier; Drug delivery; Surface property; Gastrointestinal barriers; Gastrointestinal response
资金
- National Natural Science Foundation of China [81473354]
- Double FirstClass Initiative Foundation of Chengdu University of Traditional Chinese Medicine [030041081]
Nano-carriers (NCs) provide drugs with protective and oriented strategies. Despite their success in parenteral administration, NCs still need to be optimized to meet the more serious obstacles encountered in the gastrointestinal tract (GIT). The main defense mechanisms include renewing mucus, epithelial obstacles and digestion by GIT segments. These hurdles pose challenges even before NCs target molecules or proteins, which has often led to unsatisfactory delivery efficiency. Therefore, a critical focus is the exemption from negative effects of GIT. A series of adapted NCs have been designed based on surface strategies to form an expected distribution and increase gastrointestinal utilization. In this paper, we review the strategies and efforts of NCs to adapt to gastrointestinal defense components, including the mucus, epithelium and gastrointestinal segments; the related gastrointestinal mechanisms and functions are also summarized synchronously. Last, we discuss the delivery challenges in terms of physiopathological GIT and surface properties of the NCs. (C) 2020 Elsevier Inc. All rights reserved.
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