期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 28, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2020.102213
关键词
Prostate cancer; Prostate specific membrane antigen; Ultrasound contrast agents; Nanobubbles; Ultrasound molecular imaging
资金
- National Institutes of Health [R01EB025741]
- Office of the Assistant Secretary of Defense for Health Affairs, through the Prostate Cancer Research Program [W81XWH-16-1-0371, W81XWH-16-1-0372]
- Case Comprehensive Cancer Center [P30CA043703]
- National Foundation for Cancer Research (NFCR)
Contrast-enhanced ultrasound with microbubbles has shown promise in detection of prostate cancer (PCa), but sensitivity and specificity remain challenging. Targeted nanoscale-contrast agents with improved capability to accumulate in tumors may result in prolonged signal enhancement and improved detection of PCa with ultrasound. Here we report nanobubbles (NB) that specifically targets prostate specific membrane antigen (PSMA) overexpressed in PCa. The PSMA-targeted-NB (PSMA-NB) were utilized to simultaneously image dual-flank PCa (PSMA-positive PC3pip and PSMA-negative PC3flu) to examine whether the biomarker can be successfully detected and imaged in a mouse model. Results demonstrate that active targeting rapidly and selectively enhances tumor accumulation and tumor retention. Importantly, these processes could be visualized and quantified, in real-time, with clinical ultrasound. Such demonstration of the immense yet underutilized potential of ultrasound in the molecular imaging area can open the door to future opportunities for improving sensitivity and specificity of cancer detection using parametric NB-enhanced ultrasound imaging. (C) 2020 Elsevier Inc. All rights reserved.
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