期刊
NANO RESEARCH
卷 13, 期 11, 页码 3105-3109出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2980-9
关键词
ocular drug delivery; iRGD decorated liposomes; active corneal permeability; topical drops
类别
资金
- National Key S&T Special Projects [2018ZX09201018-024]
- Sichuan Province Science and Technology Plan [2019YFH0115]
Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation, resulting in low ocular bioavailability (< 5%). Worse still, the most convenient and safe route of ocular drug administration, topical administration results in a drug bioavailability of less than 1%. iRGD modified drug delivery strategies have been developed for cancer therapy, however active targeting iRGD platforms for ocular drug delivery have yet to be explored. Herein, an iRGD modified liposomes was developed for ocular drug delivery via topical administration. The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner. These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.
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