期刊
NANO LETTERS
卷 20, 期 9, 页码 6763-6773出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c02684
关键词
nanofiber hydrogel; anti-inflammatory; steroid drugs; immune checkpoint blockade; cancer immunotherapy
类别
资金
- National Research Programs of China [2016YFA0201200]
- National Natural Science Foundation of China [91959104, 21927803, 51903182, 51525203]
- Natural Science Foundation of Jiangsu Province [BK20190826]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- 111 Program from the Ministry of Education of China
Despite the great promise achieved by immune checkpoint blockade (ICB) therapy in harnessing the immune system to combat different tumors, limitations such as low objective response rates and adverse effects remain to be resolved. Here, an anti-inflammatory nanofiber hydrogel self-assembled by steroid drugs is developed for local delivery of antiprogrammed cell death protein ligand 1 (alpha PDL1). Interestingly, on the one hand this carrier-free system based on steroid drugs can reprogram the pro-tumoral immunosuppressive tumor microenvironment (TME) to antitumoral TME; on the other hand, it would serve as a reservoir for sustained release of alpha PDL1 so as to synergistically boost the immune system. By local injection of such alpha PDL1-loaded hydrogel, effective therapeutic effects were observed in inhibiting both local tumors and abscopal tumors without any treatment. This work presents a unique hydrogel-based delivery system using clinically approved drugs, showing promise in improving the objective response rate of ICB therapy and minimizing its systemic toxicity.
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