期刊
NANO LETTERS
卷 20, 期 7, 页码 4842-4849出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c00817
关键词
iron-tannic acid network; dual-mode MR imaging; PTT material; drug delivery platform; combination theranostic therapy
类别
资金
- National Key Research and Development Program of China [2017YFA0205402]
- National Natural Science Foundation of China [81803477, 81872817]
- Natural Science Foundation of Jiangsu Province [BK20180557]
- Jiangsu Fund for Distinguished Youth [BK20170028]
- Double First-Class University Project of China Pharmaceutical University [CPU2018GY07]
Development of T-1/T-2 dual-mode MRI contrast agents that can also treat cancer is an attractive prospect for personalized precision medicine. Unfortunately, conventional contrast agents can suffer from toxicity and lack any ability to treat cancer. An all-iron T-1/T-2 MR imaging agent with photothermal and drug delivery capability would overcome these issues. Here, an avocado-like Fe3+/Fe2O3 composed T-1-T-2 dual-mode contrast agent based on Fe-TA coordination network (CNMN) is developed. This material possesses suitable longitudinal and transverse relaxation coefficients. Moreover, the strong heat generation property of Fe-TA endows CNMN with the capability to act as a potent photothermal agent. Furthermore, CNMN can also act as an effective delivery platform for the chemotherapeutic drug doxorubicin (DOX) to achieve high effective chemo-photothermal combination therapy. The work demonstrates reliable T-1-T-2 MRI-guided chemo-photothermal therapy for safe and effective clinical application.
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