期刊
NANO LETTERS
卷 20, 期 7, 页码 5106-5110出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c01305
关键词
molecular imprinting; receptor; binding; molecular recognition; glycan; micelle
类别
资金
- NIGMS [R01GM113883]
Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据