期刊
MOLECULES
卷 25, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/molecules25153346
关键词
Alnus japonica; lignan; adipogenesis; FOXO1
资金
- National Research Foundation of Korea (NRF) - Korea government [NRF-2018R1D1A1B07049941]
- SookmyungWomen's University Specialization Program Funding [SP1-201809-6]
In the present study, we isolated a lignan ((-)-(2R,3R)-1,4-O-diferuloylsecoisolariciresinol, DFS) fromAlnus japonicaand evaluated its antiobesity potential in vitro. We also determined its mechanism of action in a mouse pre-adipocyte 3T3-L1 cell line. DFS dose- and day-dependently inhibited adipogenesis by downregulation of adipogenic factors and lipid metabolism-regulating factors during adipocyte differentiation. In particular, DFS suppressed cell cycle-regulating factors and induced G0/G1 cell cycle arrest, implying that it had an inhibitory effect on mitotic clonal expansion which occurred at an early stage of adipogenesis. DFS also suppressed adipogenesis through decreasing Akt phosphorylation and increasing the level of Forkhead box protein-O1 (FOXO1). These results suggest that DFS may be a pharmacological candidate for the development of antiobesity, therapeutic, and nutraceutical products.
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