期刊
MOLECULES
卷 25, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/molecules25143264
关键词
fluorination; trifluoromethylation; trifluoromethylthiolation; beta-keto esters; asymmetric
资金
- Spanish Ministerio de Economia, Industria y Competitividad (MINECO) [CTQ2016-81797-REDC, RED2018-102387-T]
- Spanish Ministerio de Ciencia, Innovacion y Universidades (MCIU) [RTI2018-097853-B-I00]
- DURSI-Generalitat de Catalunya [SGR2017-0465]
In this review, recent advances over the past decade in the preparation of fluorinated stereogenic quaternary centers on beta-keto esters compounds are analyzed. Since the incorporation of fluorine and fluorinated groups is of special interest in pharmaceutical chemistry, a range of metal-catalyzed and organocatalyzed methods have been developed. Herein, we review the enantioselective fluorination, trifluoromethylation and trifluoromethylthiolation of 3-oxo esters. The scope, the induction of enantioselectivity and mechanistic investigations are presented.
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