期刊
MOLECULES
卷 25, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules25122885
关键词
stilbene; chemical proteomics; SNARE complex; insulin
资金
- MIUR ITALY PRIN 2017 Intestinal microbiota, bile acids activated receptors and metabolism: development of novel therapeutic targets in the treatment of steato-hepatitis (NASH) [2017FJZZRC]
- Universita di Salerno-Fondi di Ateneo per la ricerca di base (FARB ex 60%)-anno 2018 [ORSA183189]
Pterostilbene, the 3,5-dimethoxy derivative of resveratrol, is a well-known polyphenolic compound, mainly found in blueberries, grapevines, andPterocarpus marsupiumheartwood, which has recently attracted a great deal of attention due to its wide bio-pharmacological profile. Moreover, pterostilbene is more lipophilic than resveratrol, with a consequently better bioavailability and a more interesting therapeutic potential. In this work, a chemoproteomic approach, based on affinity chromatography, was applied on pterostilbene in the attempt to identify the biological targets responsible for its bioactivity. On this basis, syntaxins, a group of proteins involved in the formation of SNARE complexes mediating vesicles exocytosis, were selected among the most interesting pterostilbene interactors. In vitro and in cell assays gave evidence of the pterostilbene ability to reduce insulin secretion on glucose-stimulated pancreatic beta cells, opening the way to potential applications of pterostilbene as a supplement in the care of insulin-dependent metabolic disorders.
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