期刊
MOLECULAR PSYCHIATRY
卷 26, 期 9, 页码 4896-4904出版社
SPRINGERNATURE
DOI: 10.1038/s41380-020-0783-8
关键词
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资金
- UK Medical Research Council [MR/M021475/1]
- US National Institutes of Health [HD044454, HD059215, AG046903]
- European Commission [602768]
This study examined the genetic architecture of Environmental Sensitivity (ES) through twin design methodology. The heritability of sensitivity was found to be 0.47, with genetic influences on sensitivity to negative experiences distinct from those on sensitivity to positive aspects of the environment. The correlation between sensitivity, neuroticism, and extraversion was largely explained by shared genetic influences, with unique environmental influences accounting for differences between these traits.
Humans differ substantially in how strongly they respond to similar experiences. Theory suggests that such individual differences in susceptibility to environmental influences have a genetic basis. The present study investigated the genetic architecture of Environmental Sensitivity (ES) by estimating its heritability, exploring the presence of multiple heritable components and its genetic overlap with common personality traits. ES was measured with the Highly Sensitive Child (HSC) questionnaire and heritability estimates were obtained using classic twin design methodology in a sample of 2868 adolescent twins. Results indicate that the heritability of sensitivity was 0.47, and that the genetic influences underlying sensitivity to negative experiences are relatively distinct from sensitivity to more positive aspects of the environment, supporting a multi-dimensional genetic model of ES. The correlation between sensitivity, neuroticism and extraversion was largely explained by shared genetic influences, with differences between these traits mainly attributed to unique environmental influences operating on each trait.
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