期刊
MOLECULAR PHARMACEUTICS
卷 18, 期 2, 页码 539-549出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.0c00295
关键词
delivery; inflamed joint; nanoparticle; stimulus; targeting; therapy
资金
- Basic Science Research Program through the National Research Foundation [NRF-2017R1E1A1A01074847]
- Ministry of Science and ICT, Republic of Korea
Nanomedicine is a new therapeutic strategy that can efficiently localize drugs in inflamed joints for the treatment of rheumatoid arthritis. It focuses on targeted delivery, controlled drug release, and immune modulation to manage the progression of RA.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that results in severe inflammatory microenvironments in the joint tissues. In clinics, disease-modifying antirheumatic drugs (DMARDs) are generally prescribed to patients with RA, but their long-term use often shows toxicity in some organs such as the gastrointestinal system, skin, and kidneys and immunosuppression-mediated infection. Nanomedicine has emerged as a new therapeutic strategy to efficiently localize the drugs in inflamed joints for the treatment of RA. In this Review, we introduce recent research in the area of nanomedicine for the treatment of RA and discuss how the nanomedicine can be used to deliver therapeutic agents to the inflamed joints and manage the progression of RA, particularly focusing on targeted delivery, controlled drug release, and immune modulation.
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