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Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease

期刊

出版社

WILEY
DOI: 10.1002/mnfr.202000023

关键词

alcoholic liver disease; microbiome; mycobiome

资金

  1. NIH [R01 AA24726, R01AA020703, U01 AA026939]
  2. Biomedical Laboratory Research & Development Service of the VA Office of Research and Development [BX004594]
  3. San Diego Digestive Diseases Research Center [P30 DK120515]
  4. Biocodex Microbiota Foundation

向作者/读者索取更多资源

Alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and gut microbiota, communicating with the liver through the gut-liver axis. Some microbial products and metabolites reviewed in this article may serve as therapeutic targets for alcohol-related liver disease.
As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, beta-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.

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