期刊
MOLECULAR NEUROBIOLOGY
卷 57, 期 11, 页码 4657-4666出版社
SPRINGER
DOI: 10.1007/s12035-020-02055-5
关键词
Glycogen; Long-term potentiation; Plasticity; Epilepsy; Astrocyte; Metabolism
资金
- MINECO [BFU2017-82375-R, RTI2018-099773B-I00, BFU2017-84345-P]
- CIBER de Diabetes y Enfermedades Metabolicas Asociadas (ISCIII, Ministerio de Ciencia e Innovacion)
- National Institutes of Health [NIH NINDS P01NS097197]
- la Caixa Foundation [100010434, LCF/PR/HR19/52160007]
- European Union [754510]
Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons.By conditional deletion of glycogen synthase (GYS1), we previously developed a mouse model entirely devoid of glycogen in the central nervous system (GYS1(Nestin-KO)). These mice displayed altered electrophysiological properties in the hippocampus and increased susceptibility to kainate-induced seizures. To understand which of these functions are related to astrocytic glycogen, in the present study, we generated a mouse model in which glycogen synthesis is eliminated specifically in astrocytes (GYS1(Gfap-KO)). Electrophysiological recordings of awake behaving mice revealed alterations in input/output curves and impaired long-term potentiation, similar, but to a lesser extent, to those obtained with GYS1(Nestin-KO)mice. Surprisingly, GYS1(Gfap-KO)mice displayed no change in susceptibility to kainate-induced seizures as determined by fEPSP recordings and video monitoring. These results confirm the importance of astrocytic glycogen in synaptic plasticity.
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