期刊
MOLECULAR CANCER
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12943-020-01233-2
关键词
Noncoding RNAs; Cancer; m(6)A RNA methylation
资金
- National Natural Science Foundation of China [81873143]
- Double-Hundred Talent Plan of Shanghai Jiao Tong University School of Medicine [20191831]
N6-methyladenosine (m(6)A) is one of the most common RNA modifications in eukaryotes, mainly in messenger RNA (mRNA). Increasing evidence shows that m(6)A methylation modification acts an essential role in various physiological and pathological bioprocesses. Noncoding RNAs (ncRNAs), including miRNAs, lncRNAs and circRNAs, are known to participate in regulating cell differentiation, angiogenesis, immune response, inflammatory response and carcinogenesis. m(6)A regulators, such as METTL3, ALKBH5 and IGF2BP1 have been reported to execute a m(6)A-dependent modification of ncRNAs involved in carcinogenesis. Meanwhile, ncRNAs can target or modulate m(6)A regulators to influence cancer development. In this review, we provide an insight into the interplay between m(6)A modification and ncRNAs in cancer.
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