期刊
MOLECULAR CANCER
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12943-020-01238-x
关键词
Innate immunity; Natural killer cell; Tumor progression; Immunometabolism; Immunotherapy; Precision treatment
资金
- National Natural Science Foundation of China [81922048, 81874112, 81874113, 81572583, 81502278]
- Fok Ying-Tong Education Foundation for College Young Teachers [171034]
- Training Plan of Excellent Talents in Shanghai Municipality Health System [2017YQ038]
- Shanghai Municipal Education Commission [17CG01]
- Shanghai Education Development Foundation [17CG01]
- Shanghai Pujiang Program [18PJD007]
- Training Plan of Excellent Talents of Fudan University Shanghai Cancer Center [YJYQ201602]
The tumor microenvironment is highly complex, and immune escape is currently considered an important hallmark of cancer, largely contributing to tumor progression and metastasis. Named for their capability of killing target cells autonomously, natural killer (NK) cells serve as the main effector cells toward cancer in innate immunity and are highly heterogeneous in the microenvironment. Most current treatment options harnessing the tumor microenvironment focus on T cell-immunity, either by promoting activating signals or suppressing inhibitory ones. The limited success achieved by T cell immunotherapy highlights the importance of developing new-generation immunotherapeutics, for example utilizing previously ignored NK cells. Although tumors also evolve to resist NK cell-induced cytotoxicity, cytokine supplement, blockade of suppressive molecules and genetic engineering of NK cells may overcome such resistance with great promise in both solid and hematological malignancies. In this review, we summarized the fundamental characteristics and recent advances of NK cells within tumor immunometabolic microenvironment, and discussed potential application and limitations of emerging NK cell-based therapeutic strategies in the era of presicion medicine.
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