期刊
MOLECULAR BIOTECHNOLOGY
卷 62, 期 8, 页码 355-363出版社
HUMANA PRESS INC
DOI: 10.1007/s12033-020-00258-8
关键词
CRISPR; dCas9; Delivery
资金
- the National Key Specialty Construction Project of Clinical Pharmacy [Grant no.30305030698] Funding Source: Medline
- the Science & Technology Program of Sichuan Province [Grant nos. 2009SZ0226, 2014FZ0103, 2015JQO027, and 2015ZR0160] Funding Source: Medline
- Chengdu City Science and Technology Project [Grant no.11PPYB010SF-289] Funding Source: Medline
- ZambonPharmaceutical Scientific Research Foundation of the Chengdu Pharmaceutical Association [Grant No. 201905] Funding Source: Medline
- the Young Scholars Foundation of Sichuan Provincial People's Hospital [Grant nos. 30305030606 and 30305030859] Funding Source: Medline
- the Health Department of Sichuan Province [Grant nos. 100491, 120111, and 17ZD038] Funding Source: Medline
- the Cadre Health Care Research Project of Sichuan Province [Grant No. 2019-801] Funding Source: Medline
- Sichuan Cancer Hospital [Grant no. YB2019001] Funding Source: Medline
As gene-editing technology has become more and more popular in the life sciences, CRISPR has brought good news to scientific researchers because of its efficiency, convenience, and wide application. Its wide application has also promoted the development of basic scientific research, agriculture, basic medicine, and clinical treatment. However, how the CRISPR/dCas9 system is effectively delivered to the target organs or cells is still unknown. This paper briefly introduces the CRISPR/dCas9 system and then lists some common delivery methods and their characteristics.
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