期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 37, 期 10, 页码 2989-3002出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msaa172
关键词
genetic network; adaptation; experimental evolution; fitness landscape; oxidative stress; evolvability
资金
- FWO [SB/1S17117N]
- Fonds voor Wetenschappelijk Onderzoek (FWO)
- KU Leuven Program Financing
- European Research Council (ERC) [CoG682009]
- Vlaams Instituut voor Biotechnologie (VIB)
- European Molecular Biology Organization (EMBO) Young Investigator Program
- VLAIO
- KU Leuven [C14/16/060]
Loss of gene function is common throughout evolution, even though it often leads to reduced fitness. In this study, we systematically evaluated how an organism adapts after deleting genes that are important for growth under oxidative stress. By evolving, sequencing, and phenotyping over 200 yeast lineages, we found that gene loss can enhance an organism's capacity to evolve and adapt. Although gene loss often led to an immediate decrease in fitness, many mutants rapidly acquired suppressor mutations that restored fitness. Depending on the strain's genotype, some ultimately even attained higher fitness levels than similarly adapted wild-type cells. Further, cells with deletions in different modules of the genetic network followed distinct and predictable mutational trajectories. Finally, losing highly connected genes increased evolvability by facilitating the emergence of a more diverse array of phenotypes after adaptation. Together, our findings show that loss of specific parts of a genetic network can facilitate adaptation by opening alternative evolutionary paths.
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