期刊
MINI-REVIEWS IN ORGANIC CHEMISTRY
卷 18, 期 2, 页码 173-195出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570193X17999200629155733
关键词
[F-18]fluorine; aryliodonium compound; fluoroarene; late-stage fluorination; PET imaging; radiosynthesis
资金
- JSPS [18H02014, 19K05466]
- Ritsumeikan Global Innovation Research Organization (R-GIRO) project
- Ritsumeikan University, Japan
- Grants-in-Aid for Scientific Research [19K05466, 18H02014] Funding Source: KAKEN
The use of [F-18]-labeled drugs and radioligands is common in PET radiopharmaceuticals for clinical and preclinical research. Various methods for introducing [F-18]fluorine into complex molecules through fluorination reactions have been reported. Recent advances in [F-18]-fluorination using aryliodonium(III) compounds are highlighted in this study.
[F-18]-labeled drugs and radioligands are most frequently used in positron-emission tomography (PET) radiopharmaceuticals for both clinical and preclinical research. Various methods for the introduction of [F-18]fluorine into complex molecules through fluorination reactions have been reported. Herein, recent advances in [F-18]-fluorination utilizing aryliodonium(III) compounds are high-lighted.
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