Progress in [18F]Fluorination by Using Aryliodonium(III) Compounds and Application for PET Tracer Syntheses

[F-18]-labeled drugs and radioligands are most frequently used in positron-emission tomography (PET) radiopharmaceuticals for both clinical and preclinical research. Various methods for the introduction of [F-18]fluorine into complex molecules through fluorination reactions have been reported. Herein, recent advances in [F-18]-fluorination utilizing aryliodonium(III) compounds are high-lighted.

Automated summary

The use of [F-18]-labeled drugs and radioligands is common in PET radiopharmaceuticals for clinical and preclinical research. Various methods for introducing [F-18]fluorine into complex molecules through fluorination reactions have been reported. Recent advances in [F-18]-fluorination using aryliodonium(III) compounds are highlighted in this study.