期刊
MICROSCOPY RESEARCH AND TECHNIQUE
卷 84, 期 1, 页码 38-41出版社
WILEY
DOI: 10.1002/jemt.23561
关键词
3D; mouse; phase-contrast X-ray; single muscle fiber; synchrotron; volume rendering
资金
- Health Fellowship Foundation
- Soonchunhyang University Research Fund
This study introduces a novel method for analyzing single muscle fibers with injury conditions in three dimensions, visually and quantitatively analyzing the severity of muscle fiber injuries through phase-contrast X-ray projection microstructure visualization. The individual muscle conditions of multiple individuals were determined, contributing to areas such as new drug development requiring detailed and quantitative identification of state changes.
Muscle damage can reduces the biological functions and lead to ultimately a disease state. For the reason, it is important to accurately check the state of an injury such as atrophy, and it is required to identify the state of fibers constituting the muscle. This study describes a novel method of analyzing single muscle fibers with injury conditions in three-dimensions. The muscle fibers of the mice were visualized using phase-contrast X-ray projection the microstructure. In additions, it was possible to confirm the status by quantitatively analyzing the injury severity of muscle fibers. Significantly, the muscle conditions of multiple individuals were individually determined. This study could contributes to areas where it is very important to identify microdetailed and quantitative changes of state, such as new drug development.
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