Electrochemical assays for determination of H2O2and prostate-specific antigen based on a nanocomposite consisting of CeO2nanoparticle-decorated MnO2nanospheres

A nanocomposite consisting of CeO(2)nanoparticle-decorated MnO(2)nanospheres (CeO2@MnO2) was synthesized for the first time viaa hydrothermal method. CeO2@MnO(2)was exploited to construct an electrochemical assays for detecting H(2)O(2)and prostate-specific antigen (PSA) with square wave voltammetry (SWV). The electrochemical results proved that CeO2@MnO(2)owned a better electrocatalytic effect towards H(2)O(2)reduction than pure MnO2NS and CeO2NP due to the synergistic effect between MnO2NS and CeO2NP. Under optimized conditions, CeO2@MnO2-based assay can be applied to detect H(2)O(2)in the range 1 to 3.0 x 10(3) mu mol L-1. The label-free electrochemical immunoassay based on CeO2@MnO(2)displayed linearly with concentrations of PSA from 0.005 to 50.0 ng mL(-1). The electrochemical assays also possessed acceptable sensitivity, selectivity, and stability. The study showed that CeO2@MnO(2)hold great potential as a biosensing platform and the clinical determination of tumor markers in human serum.