期刊
MICROBIOLOGY-SGM
卷 166, 期 7, 页码 614-616出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.000958
关键词
Komagataella; budding yeast; methylotroph; yeast biotechnology; protein production
类别
资金
- Austrian BMDW
- Nationalstiftung FTE through the Christian Doppler Research Association
- BMK
- BMDW
- SFG
- Standortagentur Tirol
- Government of Lower Austria und Vienna Business Agency through the FFG - COMET Funding Program
- Austrian Science Fund
Methylotrophic yeasts of the genus Komagataella are abundantly found in tree exudates. Their ability to utilize methanol as carbon and energy source relies on an assimilation pathway localized in largely expanded peroxisomes, and a cytosolic metha-nol dissimilation pathway. Other substrates like glucose or glycerol are readily utilized as well. Komagataella yeasts usually grow as haploid cells and are secondary homothallic as they can switch mating type. Upon mating diploid cells sporulate readily, forming asci with four haploid spores. Their ability to secrete high amounts of heterologous proteins made them inter-esting for biotechnology, which expands today also to other products of primary and secondary metabolism.
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