期刊
MICROBES AND INFECTION
卷 22, 期 9, 页码 474-480出版社
ELSEVIER
DOI: 10.1016/j.micinf.2020.05.019
关键词
AIDS; HIV; Interleukin 1 beta; Interleukin 8; Inflammation
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
- CAPES (Brazil)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil
- Programa Estudantes-Convenio de Pos-Graduacao [PEC-PG])
- CNPq (Brazil)
- Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS) [12/2151-2]
The identification of inflammatory markers in HIV+ individuals on ART is fundamental since chronic ART-controlled HIV infection is linked to an increased inflammatory state. In this context, we assessed plasma levels of pro-inflammatory cytokines (IL-1 beta, IL-8, and IL-12p70) of HIV+ individuals who initiated ART after immunosuppression (CD4(+) T cell counts <350 cells/mm(3)). HIV+ individuals were stratified according to two extreme phenotypes: Slow Progressors (SPs; individuals with at least 8 years of infection before ART initiation) and Rapid Progressors (RPs; individuals who needed to initiate ART within 1-4 years after infection). A control group was composed of HIV-uninfected individuals. We found increased IL-8 levels (median: 5.13 pg/mL; SPs and RPs together) in HIV-infected individuals on ART as compared to controls (median: 3.2 pg/mL; p = 0.04), although no association with the progression profile (slow or rapid progressors) or CD4(+) T cell counts at sampling was observed. This result indicates that IL-8 is a general marker of chronic inflammation in HIV+ individuals on ART, independently of CD4(+) T cell counts at the beginning of the treatment or of the potential progression profile of the patient. In this sense, IL-8 may be considered a possible target for novel therapies focused on reducing inflammation in chronic HIV infection. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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