期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 22, 期 7, 页码 589-593出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2016.04.007
关键词
Maintenance immunosuppression; Opportunistic infections; Solid organ transplantation; TTV; Virome
资金
- Pasteur Institute
- Cenci Bolognetti Foundation
- Sapienza University of Rome 'Ricerche Universitarie' [2015: C26A15BABH]
Torquetenovirus (TTV) is the most abundant component of human virome. Virologists have long ignored this orphan and highly divergent virus, in part because TTV cannot be cultured and because it lacks serology reagents and animal models. Nevertheless, it is almost endemic worldwide and is insensitive to current antiviral drugs, so its monitoring is useful in various conditions. To date, TTV as a marker has proved useful in at least two circumstances: to identify anthropogenic pollution and to assess functional immune competence in immunosuppressed individuals. This review summarizes recent findings about TTV and discusses the main hurdles in translating them into clinical diagnostics. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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