期刊
MEDICINAL RESEARCH REVIEWS
卷 40, 期 6, 页码 2605-2649出版社
WILEY
DOI: 10.1002/med.21717
关键词
bioavailability; echinacoside; phenylethanoid glycosides; salidroside; verbascoside
资金
- Zhejiang Provincial Basic Public Welfare Research [LGN20C200010]
- Zhejiang Provincial Major RD Program [2019C02070]
- National Major R and D Program of China [2017YFD0400200]
- Special Project of Agricultural Product Quality Safety Risk Assessment [GJFP2019043]
- European Regional Development Fund [BG05M2OP001-1.003-001-C01]
- European Union [739582, 664620]
Phenylethanoid glycosides (PhGs) are generally water-soluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiviral, and neuroprotective properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest information on the biological activities, structure-activity relationships, mechanisms, and especially the clinical applications of PhGs will be reviewed. The bioavailability of PhGs will be summarized and factors leading to the low bioavailability will be analyzed. Recent advances in methods such as bioenhancers and nanotechnology to improve the bioavailability of PhGs are also summarized. The existing scientific gaps of PhGs in knowledge are also discussed, highlighting research directions in the future.
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