期刊
MEDICINA-LITHUANIA
卷 56, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/medicina56070336
关键词
curcumin; nanopharmaceutics; nanoparticles; cancer; health properties
资金
- Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC)
- FEDER, under the Partnership Agreement PT2020 [UIDB/04469/2020]
- National Council for Scientific and Technological Development (CNPq), Brazil [425271/2016-1]
- Coordenacao Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88887.159533/2017-00]
- Fundacao de Amparo a Pesquisa do Estado de Sergipe (FAPITEC) [88887.159533/2017-00]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 301964/2019-0 Chamada 06/2019]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Chamada CNPq) [01/2019]
- Banco do Nordeste [FUNDECI 2017.0016]
- research project: Nutraceutica come supporto nutrizionale nel paziente oncologico [CUP: B83D18000140007]
This review discusses the impact of curcumin-an aromatic phytoextract from the turmeric (Curcuma longa) rhizome-as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.
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