期刊
MEDICAL JOURNAL OF AUSTRALIA
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.5694/mja2.50726
关键词
COVID-19; Microbiology; Infectious diseases; Respiratory tract infections
资金
- National Health and Medical Research Council (NHMRC) [APP1174555]
- NHMRC Practitioner Fellowship [APP1105905]
- NHMRC Postgraduate Scholarship [GNT1191321]
- NHMRC Medical Research Future Fund [APP2002317]
Objectives To design and evaluate 3D-printed nasal swabs for collection of samples forSARS-CoV-2 testing. Design An iterative design process was employed. Laboratory evaluation includedin vitroassessment of mock nasopharyngeal samples spiked with two different concentrations of gamma-irradiatedSARS-CoV-2. A prospective clinical study comparedSARS-CoV-2 and human cellular material recovery by 3D-printed swabs and standard nasopharyngeal swabs. Setting, participants Royal Melbourne Hospital, May 2020. Participants in the clinical evaluation were 50 hospital staff members attending aCOVID-19 screening clinic and two inpatients with laboratory-confirmedCOVID-19. Intervention In the clinical evaluation, a flocked nasopharyngeal swab sample was collected with the CopanESwab and a mid-nasal sample from the other nostril was collected with the 3D-printed swab. Results In the laboratory evaluation, qualitative agreement with regard toSARS-CoV-2 detection in mock samples collected with 3D-printed swabs and two standard swabs was complete. In the clinical evaluation, qualitative agreement with regard toRNase P detection (a surrogate measure of adequate collection of human cellular material) in samples collected from 50 hospital staff members with standard and 3D-printed swabs was complete. Qualitative agreement with regard toSARS-CoV-2 detection in three pairs of 3D-printed mid-nasal and standard swab samples from two inpatients with laboratory-confirmedSARS-CoV-2 was also complete. Conclusions Using 3D-printed swabs to collect nasal samples forSARS-CoV-2 testing is feasible, acceptable to patients and health carers, and convenient.
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