期刊
MEDICAL HYPOTHESES
卷 140, 期 -, 页码 -出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2020.109648
关键词
Irritable bowel syndrome (IBS); Chronic fatigue syndrome (CFS); Fibromyalgia; Myalgic encephalopathy (ME); Intestinal dysbiosis; Dysbiotic march; Antibiotics; Lactobacilli; Candida albicans; Gut microbiota; Tryptophan metabolites; Childhood; Gut-brain axis
Irritable bowel syndrome (IBS) is often associated with other unexplained complaints like chronic fatigue syndrome (CFS), fibromyalgia and myalgic encephalopathy (ME). The pathogenesis of the relationship is unknown. Intestinal dysbiosis may be a common abnormality, but based on 1100 consecutive IBS patients examined over a nine years period, we hypothesize that the development of the disease, often from IBS to ME, actually manifests a dysbiotic march. In analogy with the atopic march in allergic diseases, we suggest a dysbiotic march in IBS; initiated by extensive use of antibiotics during childhood, often before school age. Various abdominal complaints including IBS may develop soon thereafter, while systemic symptom like CFS, fibromyalgia and ME may appear years later.
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