期刊
MATERIALS TECHNOLOGY
卷 36, 期 14, 页码 843-850出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10667857.2020.1800297
关键词
Hydrogel; wound dressing; chitosan; dextran sulphate sodium; vitamin C; quercetin
The study utilized chitosan and dextran sulphate sodium to form a pH-sensitive hydrogel suitable for wound dressing materials, with added vitamin-C and quercetin for accelerating wound healing. Experimental results showed that both loaded and unloaded hydrogels had higher cell viability rates compared to the control group at the end of the 7-day period.
In recent years, the usage of hydrogels in tissue regeneration and controlled drug release systems have been increasing rapidly due to their water holding capacity and 3D structure. In this study chitosan and dextran sulphate sodium were prefered to form pH-sensitive hydrogel by physical interaction. The biodegradability of the chitosan and the therapeutic properties of dextran sulphate sodium make them suitable as wound dressing material. In addition to these good specifications of polymers, vitamin-C and quercetin, which have an accelerating effect on wound healing. The structural and morphological characterisation of hydrogels were performed by FT-IR and SEM. The sweeling behaviour of this hydrogel was examined in PBS at different temperatures (25 degrees C and 37 degrees C) and pHs (6,7,7.4,8). In vitro release pattern of quercetin and vitamin-C were investigated. It was seen from this experiment that at the end of the 7 days, cell viability on loaded and unloaded hydrogel were higher than control group.
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