期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111324
关键词
N,O-carboxymethyl chitosan; Oxidized chondroitin sulfate; Hydrogel; Antibacterial; Hemostatic; Wound dressing
资金
- University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province [UNPYSCT-2018099]
- Harbin Application Technology Research and Development Projects (the Young Reserve Talent Type A) [2017RAQXJ039]
- Brigham Research Institute
This work reports the development of an injectable, self-healing, antibacterial, hemostatic, and biocompatible hydrogel derived from the hybrid of N,O-carboxymethyl chitosan and oxidized chondroitin sulfate, which does not require any chemical crosslinking. The hydrogel exhibited excellent in vivo hemostatic performance and low cell toxicity, making it a promising wound dressing material.
Biodegradable and injectable hydrogels derived from natural polysaccharides have attracted extensive attention in biomedical applications due to their minimal invasiveness and ability to accommodate the irregular wound surfaces. In this work, we report the development of an in-situ-injectable, self-healing, antibacterial, hemostatic, and biocompatible hydrogel derived from the hybrid of N,O-carboxymethyl chitosan (N,O-CMC) and oxidized chondroitin sulfate (OCS), which did not require any chemical crosslinking. The N,O-CMC/OCS hydrogel could be readily produced under physiological conditions by varying the N,O-CMC-to-OCS ratio, relying on the Schiff base reaction between the -NH- functional groups of N,O-CMC and the -CHO functional groups of OCS. The results showed that the N,O-CMC2/OCS1 hydrogel had relatively long gelation time (133 s) and stable performances. The viability of NIH/3T3 cells and endothelial cells cultured with the N,O-CMC2/OCS1 hydrogel extract was roughly 85%, which demonstrated its low cell toxicity. Besides, the N,O-CMC2/OCS1 hydrogel revealed excellent antibacterial properties due to the inherent antibacterial ability of N,O-CMC. Importantly, the hydrogel tightly adhered to the biological tissue and demonstrated excellent in vivo hemostatic performance. Our work describing an injectable, self-healing, antibacterial, and hemostatic hydrogel derived from polysaccharides will likely hold good potential in serving as an enabling wound dressing material.
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