期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.110770
关键词
Antimicrobial materials; Hydrogels; Antibacterial active contact lens; Microbial keratitis
资金
- European Union
- Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH - CREATE - INNOVATE [T1EDK-02990]
- COST Action Anti-Microbial Coating Innovations to prevent infectious diseases (AMICI) [CA15114]
The Metal Organic Framework (MOF) of formula {[Ag-6(mu(3)-HMNA)(4)(mu(3)-MNA)(2)](2-)center dot[(Et3NH)(+)](2)center dot(DMSO)(2)center dot(H2O)} (AGMNA), a known efficient antimicrobial compound which contains the anti-metabolite, 2-thio-nicotinic acid (H2MNA), was incorporated in polymer hydrogels using, hydroxyethyl-methacrylate (HEMA). The material pHEMA@AGMNA-1 was characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), Scanning Electron Microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), Thermogravimetric Differential Thermal Analysis (TG-DTA), Differential Scanning Calorimetry (DTG/DSC), attenuated total reflection spectroscopy (FT-IR-ATR) and Ultrasonic Imaging. The antimicrobial capacity of pHEMA@AGMNA-1 was evaluated against the Gram negative bacterial strain Pseudomonas aeruginosa and the Gram positive ones of the genus of Staphylococcus epidermidis and Staphylococcus aureus, which are the etiology of the microbial keratitis. The % bacterial viability of P. aeruginosa, S. epidermidis and S. aureus upon their incubation with pHEMA@AGMNA-1 discs is significantly low (0.4 +/- 0.1%, 1.5 +/- 0.4% and 7.7 +/- 0.5% respectively). The inhibition zones (IZ) caused by pHEMA@AGMNA-1 discs against P. aeruginosa, S. epidermidis and S. aureus are 14.0 +/- 1.1, 11.3 +/- 1.3 and 11.8 +/- 1.8 mm respectively. Furthermore, pHEMA@AGMNA-1 exhibits low toxicity. Thus, pHEMA@AGMNA-1 might be an efficient candidate for the development of antimicrobial active contact lenses.
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