期刊
MATERIALS CHEMISTRY AND PHYSICS
卷 248, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2020.122946
关键词
Phase transition of ZnSn(OH)(6) to Zn2SnO4; X-ray photoelectron spectroscopy; ROS generation; Cellular redox potential; Reduced metastasis
资金
- National Research Foundation of Korea [NRF-2019R1A5A8080290, MSIP-2018R1A2B6006056]
Engineered metal-oxide nanoparticles have greatly been used in various bio-applications, but their physicochemical properties change dramatically within a bio-system. Therefore, the development of new metal-oxide nanoparticles and proper understanding of their toxicity profile in bio-environment are very important for advancement of cancer-related diagnostic and therapeutic approaches. Nanostructured wide-bandgap semiconductors ZnSn(OH)(6) and Zn2SnO4 are fabricated by one-pot hydrothermal synthesis and tested for the first time in anti-cancer treatments. The crystalline zinc-hydroxystannate is converted by high-temperature annealing into amorphous and then crystalline zinc-orthostannate, as confirmed by Rietveld refinement analyses. A dosedependent cytotoxicity is observed when human cervical carcinoma cell lines are exposed to these nanomaterials, mainly due to the elevation of intracellular reactive-oxygen-species levels in the treated cells, which leads to oxidative stress and cell damage. The crystalline phases of the nanomaterials reveal better cell-killing efficacy due to the overlap of the conduction-band energy levels with the cellular redox potential, leading to favorable electron transfer from the biological redox couples to the conduction-band of the semiconductor nanoparticles, thus producing more reactive-oxygen-species for cell damage. Importantly, this higher reactive-oxygen-species production by the crystalline samples significantly reduces cancer cell migration and proliferation and decreases metastasis, which remains an unmet challenge in cancer therapy.
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