期刊
MARINE DRUGS
卷 18, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/md18070337
关键词
rubrolide; GNPS; Synoicum kuranui; antibacterial
资金
- VUW Doctoral Scholarship
- Curtis Gordon Research Scholarship
Global natural products social (GNPS) molecular networking is a useful tool to categorize chemical space within samples and streamline the discovery of new natural products. Here, we demonstrate its use in chemically profiling the extract of the marine tunicateSynoicum kuranui,comprised of many previously reported rubrolides, for new chemical entities. Within the rubrolide cluster, two masses that did not correspond to previously reported congeners were detected, and, following MS-guided fractionation, led to the isolation of new methylated rubrolides T (3) and (Z/E)-U (4). Both compounds showed strong growth inhibitory activity against the Gram-positive bacteriaBacillus subtilis, with minimum inhibitory concentration (MIC) values of 0.41 and 0.91 mu M, respectively.
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