期刊
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
卷 34, 期 3, 页码 367-376出版社
SPRINGER
DOI: 10.1007/s10334-020-00878-w
关键词
MRI; Fascia lata; Adipose tissue
资金
- Projekt DEAL
The developed segmentation method successfully quantified IMAT volume in thigh muscles with high precision, especially in elderly subjects where it accounted for additional adipose tissue. The segmentation approach may be useful in studying the effects of aging and treatment on changes in IMAT and fat fraction.
Objective To develop a precise semi-automated segmentation of the fascia lata (FL) of the thigh to quantify IMAT volume in T(1)w MR images and fat fraction (FF) in Dixon MR images. Materials and methods A multi-step segmentation approach was developed to identify fibrous structures of the FL and combining them into a closed 3D surface. 23 healthy young men with low and 50 elderly sarcopenic men with moderate levels of IMAT were measured by T(1)w and 6pt Dixon MRI at 3T. 20 datasets were used to determine reanalysis precision errors. IMAT volume was compared using the new FL segmentation versus an easier to segment but less accurate, tightly fitting envelope of the thigh muscle ensemble. Results The segmentation was successfully applied to all 73 datasets and took about 7 min per 28 slices. In particular, in elderly subjects, it includes a large amount of adipose tissue below the FL typically not accounted for in other segmentation approaches. Inter- and intra-operator RMS-CVs were 0.33% and 0.14%, respectively, for IMAT volume and 0.04% and 0.02%, respectively, for FFMT. Discussion The FL segmentation is an important step to quantify IMAT with high precision and may be useful to investigate effects of aging and treatment on changes of IMAT and FF. ClinicalTrials.gov identifier NCT2857660, August 5, 2016.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据