期刊
MAGNETIC RESONANCE IMAGING
卷 70, 期 -, 页码 36-42出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2020.04.002
关键词
DTI; NODDI; Disc1; Fmr1; Pten; Nrxn1
资金
- University of Wisconsin-Madison School of Medicine and Public Health and Department of Radiology
- Brain and Behavior Research Foundation (NARSAD) Young Investigator Grant
- NIH [UL1TR000427, TL1TR000429]
- University of Wisconsin Institute for Clinical and Translational Research KL2 Scholars Program [NCATS UL1TR002373]
Neuroimaging studies of psychiatric illness have revealed a broad spectrum of structural and functional perturbations that have been attributed in part to the complex genetic heterogeneity underpinning these disorders. These perturbations have been identified in both preclinical genetic models and in patients when compared to control populations, but recent work has also demonstrated strong evidence for genetic, molecular, and structural convergence of several psychiatric diseases. We explored potential similarities in neural microstructure in preclinical genetic models of ASD (Fmr1, Nrxn1, Pten) and schizophrenia (Disc1 sv Delta 2) and in age- and sex-matched control animals with diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI). Our findings demonstrate a convergence in brain microstructure across these four genetic models with both tract-based and region-of-interest based analyses, which continues to buttress an emerging understanding of converging neural microstructure in psychiatric disease.
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