4.7 Article

Dynamic Covalent Chemistry Enables Reconfigurable All-Polysaccharide Nanogels

期刊

MACROMOLECULAR RAPID COMMUNICATIONS
卷 41, 期 15, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202000213

关键词

dynamic covalent bonds; molecular recognition; polysaccharides; responsive nanogels

资金

  1. Sanofi
  2. French funding agency: Agence Nationale pour la Recherche [ANR-14-CE08-0014-01]
  3. French funding agency: FLI (France Life Imaging)
  4. French funding agency: CNRS Mission for Transversal and Interdisciplinary Initiatives

向作者/读者索取更多资源

Dynamic covalent bonds are established upon molecular recognition of sugar derivatives by boronic acid molecules. These reversible links can be used in a cross-linking method to fabricate polymer-based responsive nanosystems. Herein, the design of the first dynamic nanogels made entirely of polysaccharides (PS) is reported. Based on PS chains alternately modified with phenyl boronic acid groups and sugar moieties, these colloids self-assemble in physiological conditions and combine the biocompatible nature of their PS backbone with the reconfiguration capacities of their cross-linking chemistry. These dynamic nanogels are easily prepared, stable for a long time, pH responsive, and efficiently internalized by cancer cells.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据